The Journal of Clinical Investigation (J Clin Invest (2005) 115:2716-2730) published interesting paper finding out that atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. The study reports that zyxin and activated Akt participate in a cGMP-dependent signaling cascade leading from ANP receptors to nuclear accumulation of both molecules. It is concluded that nuclear accumulation of zyxin and activated Akt may represent a fundamental mechanism that facilitates nuclear-signal transduction and potentiates cell survival. The paper is written by the Mark Sussman`s team from San Diego State University Heart Institute. Dr. Sussman and colleagues used CoLocalizer Pro software for quantifying TUNEL positive nuclei. The Journal of Clinical Investigation (JCI) is a top-tier journal publishing biologically significant findings with clinical relevance. Published since 1924, the JCI has a 2004 Impact Factor of 14.204.
