Tyrosine phosphorylation and lipid raft association of pseudorabies virus

Virology, the leading source of new information in its field (2007 362:60-66), published an article of Dr. Desplanques and colleagues from Ghen University, Belgium, on tyrosine phosphorylation and association of lipid raft of pseudorabies virus (PRV) glycoprotein E during antibody-mediated capping. It was found that PRV gE-mediated viral capping process results in increased Src kinase-mediated tyrosine phosphorylation of the cytoplasmic domain of gE and that a fraction of gE associates with lipid rafts, all very reminiscent of immunoreceptor capping. These results provide evidence that gE-mediated capping is a viral mimicry of immunoreceptor capping. The authors made a good use of CoLocalizer Pro software not only performing calculations of various colocalization coefficients, but analyzing scatter grams of images as well. Interesting that images used for quantification of colocalization in this study were selected for the journal issue cover. Good job!