Proceedings of the National Academy of Sciences the United States of America (PNAS), one of the most respected and highly acclaimed scientific journals, published in its June issue (104: 10205-10210, 2007) a very interesting article about involvement of host cellular multivesicular body functions in hepatitis B virus budding. The paper was written by Dr. Watanabe and colleagues from Institute for Molecular Virology, McArdle Laboratory for Cancer Research and Howard Hughes Medical Institute, University of Wisconsin, Madison. The authors found that host multivesicular bodies (MVBs) functions are required for efficient budding and release of enveloped Hepatitis B virus (HBV) virions and may be a valuable target for HBV control. Moreover, HBV enveloped virions, enveloped subviral particles, and unenveloped nucleocapsids are all released by distinct pathways with separate host factor requirements. The study elegantly used CoLocalizer Pro software to estimate colocalization of HBV envelope protein with class E proteins in Huh-7 cells.
Tuesday, October 23, 2007
Interesting article published by PNAS
Proceedings of the National Academy of Sciences the United States of America (PNAS), one of the most respected and highly acclaimed scientific journals, published in its June issue (104: 10205-10210, 2007) a very interesting article about involvement of host cellular multivesicular body functions in hepatitis B virus budding. The paper was written by Dr. Watanabe and colleagues from Institute for Molecular Virology, McArdle Laboratory for Cancer Research and Howard Hughes Medical Institute, University of Wisconsin, Madison. The authors found that host multivesicular bodies (MVBs) functions are required for efficient budding and release of enveloped Hepatitis B virus (HBV) virions and may be a valuable target for HBV control. Moreover, HBV enveloped virions, enveloped subviral particles, and unenveloped nucleocapsids are all released by distinct pathways with separate host factor requirements. The study elegantly used CoLocalizer Pro software to estimate colocalization of HBV envelope protein with class E proteins in Huh-7 cells.
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