CoLocalizer Pro is an Apple.com featured download

CoLocalizer Pro version 1.4 is a featured download on Math & Science page of Apple.com Downloads page. We hope that many more researchers will now learn about our software and use it for their studies with great success.

CoLocalizer Pro is used to obtain data published in The Journal of Clinical Investigation

The Journal of Clinical Investigation (J Clin Invest (2005) 115:2716-2730) published interesting paper finding out that atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. The study reports that zyxin and activated Akt participate in a cGMP-dependent signaling cascade leading from ANP receptors to nuclear accumulation of both molecules. It is concluded that nuclear accumulation of zyxin and activated Akt may represent a fundamental mechanism that facilitates nuclear-signal transduction and potentiates cell survival. The paper is written by the Mark Sussman`s team from San Diego State University Heart Institute. Dr. Sussman and colleagues used CoLocalizer Pro software for quantifying TUNEL positive nuclei. The Journal of Clinical Investigation (JCI) is a top-tier journal publishing biologically significant findings with clinical relevance. Published since 1924, the JCI has a 2004 Impact Factor of 14.204.

CoLocalizer Express released!

We have released new application, CoLocalizer Express. It is a lite version of CoLocalizer Pro. CoLocalizer Express suits best to labs on little budget. It employs power and flexibility of CoLocalizer Pro and guarantees that you will obtain your calculation results very quickly. If you do not need image viewing capabilities of CoLocalizer Pro and can be satisfied with saving results in a simple way, CoLocalizer Express is a program for you. Standard Single-User license of CoLocalizer Express costs $99 (US), Academic Single-User license costs $89 (US). Lab license sells for $249 (US). Similarly to CoLocalizer Pro, you may try CoLocalizer Express for 1 week before purchasing its license.

Our latest paper appeared In Microscopy Research and Technique

Microscopy Research and Technique (MRT) in its June issue published our paper entitled "Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study". You can read it here:
http://www3.interscience.wiley.com/cgi-bin/abstract/110573293/ABSTRACT
Interesting thing about this article is that, in addition to Pearson's correlation coefficient and Overlap coefficient according to Manders, we used this time Overlap coefficients k1 and k2 as well to present the significance of the changes of colocalization of Mrp2 and Bsep proteins in dynamics of pathological process. MRT made a proper layout of tables and graphs in the paper so that the significance of our data is easily seen. MRT is a leading journal in the field of modern microscopy and we hope that our article will attract attention of many specialists in the field.

New look of CoLocalization Research Software web site

As we are preparing new application, CoLocalizer Express, we have decided to refresh our site. We included more information, such as about us, frequently asked questions, support, and much more. We have also added News section as well as created space for special announcements. Special announcement at this time is start of the BACK TO THE LAB campaign.

BACK TO THE LAB campaign, Lab licensing

We kicked off CoLocalizer Pro BACK TO THE LAB campaign and introduced its Lab licensing. Users who register CoLocalzier Pro before August 31, 2005 are eligible for 10% discount. Under requests, we have also introduced new Lab licensing. Lab license costs $899 (USD) and is offered to labs where several researchers require the software. It allows full access to the features of the program for all members of a lab. We strongly recommend to users who emailed us and asked about Multi-User discount option consider it as this is the smartest CoLocalizer Pro registration money can buy.

New application under development

We decided to create a new application. We named it CoLocalizer Express. It will be a lite version of CoLocalizer Pro designed specifically for the labs on little budget. It will be priced under $100 (US). In addition, we will also offer a discounted Multi-User license, a Lab license. This license will allow full access to the features of the program for all members of a lab.

CoLocalizer Pro 1.3 is available!

We have released CoLocalizer Pro 1.3. It is a free update to all registered users and has an important new feature, Merge. In addition, we rearranged built-in Help making it even easier to navigate, and added more information about analyzed image file to Show Info window. With this release, CoLocalizer Pro positions itself as a powerful application for the researchers working on the cutting-edge of cellular and molecular biology. If you like this release, help spread a word about it. If you have any questions, please email our Support Team.

Ready your images for CoLocalizer Pro 1.3

We are putting finishing touches on CoLocalizer Pro version 1.3. This version will bring an important new feature, Merge. Previously, CoLocalizer Pro users who save results of colocalization experiments as single channel images needed to use other apps to merger them into one before importing into CoLocalizer Pro. Starting from version 1.3, they can do it easily and smoothly with CoLocalizer Pro.

CoLocalizer Pro 1.3 runs flawlessly on Mac OS X 10.4 Tiger. Our registered users who upgraded to Tiger will have no problem running this new version of CoLocalizer Pro (as well as all previous versions).

CoLocalizer Pro 1.3 will be a completely free update. I am convinced that everyone will love this release.

Microscopy Research and Technique (MRT) accepts our newest paper

Our paper entitled "Experimental LPS-induced cholestais alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study" has been accepted for publication in Microscopy Research and Technique (MRT). This respected international journal publishes articles on all aspects of advanced microscopy in the biological, clinical, chemical, and materials sciences. MRT attracts attention of researchers looking for new, reliable, and advanced tools for their microscopy studies. We are very pleased that many new investigators will be able to see the usefulness of CoLocalizer Pro software for their studies.

CoLocalizer Pro 1.2.1 released

We have updated CoLocalizer Pro to version 1.2.1. This update fixes the m2 coefficient issue. We recommend to all CoLocalizer Pro registered users download and install this update. Enjoy.

Very interesting paper appeared in Blood

Dr. Brian Eliceiri, Registered User of CoLocalizer Pro from the Institute for Molecular Medicine in La Jolla, CA, and his colleagues published interesting study about the dependency of tumor metastasis, not tumor growth, on Src-mediated vascular permeability. Src, the non-receptor tyrosine kinase, plays an essential role in specific VEGF (vascular endothelial growth factor/vascular permeability (VP) factor) pathway signaling responses. The authors used CoLocalizer Pro software to quantify colocalization of fibrin/FDPs and CD31, markers of vascular endothelial cells, in perivascular spaces of tumors of control (src +/- and wildtype) and src -/- mice. A conclusive difference of the degree of colocalization of them was found. The study suggests that there are defects in VP in the primary site of Src-deficient mice and that there may be an essential role for Src and Src-mediated VP in tumor metastasis to the lung. The paper appeared in Blood (2005, 105: 1508-1514), a highly respected Journal of the American Society of Hematology (Impact Factor 10.12, 2003).

CoLocalizer Pro 1.2 released

We have just released CoLocalizer Pro version 1.2. In this version, we listened to the majority of our users` requests and gave more options for background correction! Background correction has now Auto and Manual modes. In the Manual mode, there are three presets depending upon the image pattern: Average Contrast and Fluorescence, Low Contrast, and Weak Fluorescence. Auto mode should be used by users whose images do not require a very precise correction and should work for the majority of them. It should appeal to the users who want get things done really quickly. For other images and more precision, use Manual mode. We also made several minor enhancements, updated documentation, and tweaked the interface. Enjoy.