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Tuesday, February 06, 2007

Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes

International Immunology (Int Immunol (2007) 19:19-30), new but already highly respected journal in the field of immunology, published interesting article about role of activation-induced endocytosis of the raft-associated transmembrane adaptor protein Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) in B lymphocytes in internalization of the B cell receptor (BCR). The authors lead by Dr. Deans from Department of Biochemistry and Molecular Biology at the University of Calgary used a complex methodological approach, which included quantitative colocalization analysis using CoLocalizer Pro software. The paper sheds light onto the role of LAB/NTAL in the internalization of BCR and describes intrinsic details of this process. Congratulations to the authors on this elegant study.