Very interesting paper appeared in Blood

Dr. Brian Eliceiri, Registered User of CoLocalizer Pro from the Institute for Molecular Medicine in La Jolla, CA, and his colleagues published interesting study about the dependency of tumor metastasis, not tumor growth, on Src-mediated vascular permeability. Src, the non-receptor tyrosine kinase, plays an essential role in specific VEGF (vascular endothelial growth factor/vascular permeability (VP) factor) pathway signaling responses. The authors used CoLocalizer Pro software to quantify colocalization of fibrin/FDPs and CD31, markers of vascular endothelial cells, in perivascular spaces of tumors of control (src +/- and wildtype) and src -/- mice. A conclusive difference of the degree of colocalization of them was found. The study suggests that there are defects in VP in the primary site of Src-deficient mice and that there may be an essential role for Src and Src-mediated VP in tumor metastasis to the lung. The paper appeared in Blood (2005, 105: 1508-1514), a highly respected Journal of the American Society of Hematology (Impact Factor 10.12, 2003).