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Monday, March 12, 2007

American Journal of Pathology paper cites CoLocalizer Express software

Dr. Rocker and colleagues from departments of biophysics and cardiology at the University of Ulm and physics at the University of Illinois at Urbana–Champaign published interesting article about enhancement of the affinity of C-reactive protein toward FcgammaRI by the gamma-chain. The publication appeared in American Journal of Pathology (2007) 170:755-763, an official journal of the American Society for Investigative Pathology. This study investigates C-reactive protein (CRP), the prototype human acute phase protein, which is widely regarded as a key player in cardiovascular disease. Taking into consideration the structure of CRP, the study concludes that multivalent binding and receptor clustering are crucially involved in the interaction of CRP with nucleated cells. The article cite CoLocalizer Express software, wich has been used to understand the details of the studies processes.