Regulation of adenylyl cyclase in cultured cardiac myocytes

Journal of Biological Chemistry (JBC) editors seem to like quantitative colocalization analysis, because the journal published three articles which employed CoLocalizer Pro software in 2006 alone. This is very encouraging, because JBC is one of the best journals in the medico-biological field. The paper which I did not mention here yet is written by Dr. Head and colleagues from the University of California in San Diego (J Biol Chem (2006) 281:38730-38737). It reports about regulation of localization of adenylyl cyclase in cultured cardiac myocytes. In an elegant way, Dr. Head and coworkers showed that microtubules and actin filaments restrict formation of cyclic AMP by regulating the localization and interaction of G protein-coupled receptors with adenylyl cyclase in lipid rafts/caveolae. The paper is an interesting read.

CoLocalizer Express 1.2 released!

We have updated CoLocalizer Express to version 1.2. This update is a universal binary version. It includes updates to the Help and User Guides and to the License Agreement. It can be downloaded here: http://homepage.mac.com/colocalizerpro/purchasesupport.html. Enjoy!