
Dr. Tstutsumi and colleagues from University of California in San Diego reported results of their study about role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. Researchers tested the hypothesis that expression and activity of 12-LO mediate delayed cardiac protection induced by isoflurane in the mouse heart in vivo. Among other tools, CoLocalizer Pro software was used in this study to find out that 12-LO is an important mediator of isoflurane-induced delayed preconditioning. Am J Physiol Heart Circ Physiol 2006, 291:H979-H983.